Sex steroid hormones

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Summary: Sex hormones are known to play a role in the development of several human cancers, including those of the female breast, endometrium, ovary, and the male prostate. In addition, there is suggestive evidence implicating sex hormones in other cancers, particularly those of the pancreas, kidney, and brain glioma, in particular. This evidence includes: 1 the presence of steroid hormone receptors in some of these cancers, 2 sex-related differences in incidence, 3 experimental evidence showing that the development of these cancers can be promoted or inhibited by sex steroid hormones; and 4 use of steroid hormone modulators in the treatment of these diseases.

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Throughout the twentieth century it has become increasingly apparent that males and females are different, and not just in terms of physical characteristics. Scientists have discovered that fundamental, gender-related differences exist in almost every cell, tissue and organ of the body, including those associated with respiration, digestion, metabolism, circulation, renal function, and neural and endocrine activity. Unable to display preview. Download preview PDF.

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Steroid sex hormones have a significant effect on different organ systems. As far as gingiva are concerned, they can influence the cellular proliferation, differentiation and growth of keratinocytes and fibroblasts. Estrogen is mainly responsible for alterations in blood vessels and progesterone stimulates the production of inflammatory mediators.

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Jane A. Cauley, Susan K. Ewing, Brent C.

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Author s : C. MeyerK. DOI :

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Esophageal adenocarcinoma EA is characterized by a strong male predominance. Sex steroid hormones have been hypothesized to underlie this sex disparity, but no population-based study to date has examined this potential association. Higher androgen:estrogen ratio metrics were associated with increased odds of EA e. All estrogens and androgens were associated with significant decreased odds of EA.

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All steroid hormones are derived from cholesterol. They are transported through the bloodstream to the cells of various target organs where they carry out the regulation of a wide range of physiological functions. These hormones often are classified according to the organs that synthesize them: the adrenal steroids are so called because they are secreted by the adrenal cortexand the sex hormones are those produced by the ovaries and testes.

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The conversion of pregnenolone to testosterone requires the action of 5 enzymesall found in the ER of the testes cells. The conversion of pregnenolone to testosterone is referred to as the " Progesterone Pathway ":. Dihydrotestosterone DHTis the most potent androgenit is formed from testosterone, by the reduction of the A ring through the action of the enzyme 5 a -Reductase. The testes also produce 17 b -estradiol, the female sex hormone in small amounts, but most of the estrogens produced by the male are derived from peripheral aromitzation of testosterone.

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